UNC 926 hydrochloride
Modify Date: 2024-01-16 17:18:42
UNC 926 hydrochloride structure
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Common Name | UNC 926 hydrochloride | ||
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| CAS Number | 1782573-49-2 | Molecular Weight | 373.72 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H22BrClN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of UNC 926 hydrochlorideUNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1]. |
| Name | UNC926 hydrochloride |
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| Description | UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor that inhibits L3MBTL1 with an IC50 of 3.9 μM[1]. |
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| Related Catalog | |
| Target |
IC50: 3.9 μM (L3MBTL1), 3.2 μM (L3MBTL3), 15.6 μM (L3MBTL4)[1] |
| In Vitro | UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7[1]. UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1[1]. |
| References |
| Molecular Formula | C16H22BrClN2O |
|---|---|
| Molecular Weight | 373.72 |