RU-SKI43 HCl structure
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Common Name | RU-SKI43 HCl | ||
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CAS Number | 1782573-67-4 | Molecular Weight | 423.012 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C22H31ClN2O2S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of RU-SKI43 HClRU-SKI 43 is an inhibitor of Hat. It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a. RU-SKI-43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR. |
Name | RU-SKI 43 (hydrochloride) |
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Synonym | More Synonyms |
Molecular Formula | C22H31ClN2O2S |
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Molecular Weight | 423.012 |
Exact Mass | 422.179474 |
2-[(2-Methylbutyl)amino]-1-{4-[(3-methylphenoxy)methyl]-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl}ethanone hydrochloride (1:1) |
MFCD25371547 |
Ethanone, 1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:1) |
RU-SKI 43 (hydrochloride) |