1782573-67-4

1782573-67-4 structure

Name: RU-SKI43 HCl
Chemical Name: RU-SKI 43 (hydrochloride)
CAS Number: 1782573-67-4
Molecular Formula: C₂₂H₃₁ClN₂O₂S
Molecular Weight: 423.012
Create Date: 2021-01-09 10:12:14
Modify Date: 2024-03-02 10:58:50
RU-SKI 43 is an inhibitor of Hat. It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a. RU-SKI-43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.

Name	RU-SKI 43 (hydrochloride)
Synonyms	2-[(2-Methylbutyl)amino]-1-{4-[(3-methylphenoxy)methyl]-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl}ethanone hydrochloride (1:1) MFCD25371547 Ethanone, 1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:1) RU-SKI 43 (hydrochloride)