Solriamfetol hydrochloride
Modify Date: 2024-01-11 15:13:16
Solriamfetol hydrochloride structure
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Common Name | Solriamfetol hydrochloride | ||
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| CAS Number | 178429-65-7 | Molecular Weight | 230.691 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H15ClN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Solriamfetol hydrochlorideSolriamfetol hydrochloride (JZP-110 hydrochloride) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol hydrochloride has robust wake-promoting effects[1][2]. |
| Name | K7RO88SP7A |
|---|---|
| Synonym | More Synonyms |
| Description | Solriamfetol hydrochloride (JZP-110 hydrochloride) is an orally active and selective dopamine and norepinephrine reuptake inhibitor with IC50s of 2.9 μM and 4.4 μM for dopamine and norepinephrine transporters, respectively. Solriamfetol hydrochloride has robust wake-promoting effects[1][2]. |
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| Related Catalog | |
| Target |
IC50: 2.9 μM (dopamine transporter) and 4.4 μM (norepinephrine transporter)[1] |
| In Vitro | Solriamfetol hydrochloride (JZP-110 hydrochloride) has the binding affinity for dopamine transporter (DAT; Ki=14,200 nM) and norepinephrine transporter (NET; Ki=3700 nM)[1]. |
| In Vivo | Solriamfetol hydrochloride (JZP-110 hydrochloride; s.c.; 10, 30 mg/kg; eight consecutive 50-minute) increases DA and NE levels in the striatum and prefrontal cortex, respectively[1]. Solriamfetol hydrochloride (i.p.; 3, 10, 30, 100 mg/kg) dose dependently decreases the rate of responding. Solriamfetol of 100 mg/kg results in a significant decrease in response rate to approximately 40% of control[1]. solriamfetol hydrochloride (po; 35 mg/kg) produces a plasma Cmax of 23.1 μM[1]. Animal Model: Male Sprague-Dawley rats weighing 200-400 g[1] Dosage: 10 and 30 mg/kg Administration: S.c.; eight consecutive 50-minute Result: Increased DA and NE levels in the striatum and prefrontal cortex, respectively. |
| References |
| Molecular Formula | C10H15ClN2O2 |
|---|---|
| Molecular Weight | 230.691 |
| Exact Mass | 230.082199 |
| K7RO88SP7A |
| (2R)-2-Amino-3-phenylpropyl carbamate hydrochloride (1:1) |
| Benzenepropanol, β-amino-, carbamate (ester), (βR)-, hydrochloride (1:1) |