Butyl isobutyl phthalate

Modify Date: 2024-01-03 06:24:57

Butyl isobutyl phthalate structure	Common Name	Butyl isobutyl phthalate
	CAS Number	17851-53-5	Molecular Weight	278.344
	Density	1.1±0.1 g/cm3	Boiling Point	315.7±10.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₂₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	165.4±8.5 °C

Use of Butyl isobutyl phthalate

Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment[1].

Name	1-O-butyl 2-O-(2-methylpropyl) benzene-1,2-dicarboxylate
Synonym	More Synonyms

Description	Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	IC50: 38 μM (α-glucosidase)[1]
In Vitro	Butyl isobutyl phthalate exhibits significant, concentration-dependent inhibitory activity against α-glucosidase with an IC50 value of 38 μM[1].
In Vivo	Butyl isobutyl phthalate (intragastric administration; 25, 50 or 100 mg/kg; 3 days) results in a more significant reduction in the blood glucose level, with the concentration of blood glucose being 11.50, 8.60 and 6.50 mM, respectively[1]. Animal Model: Streptozocin induced diabetic mice (Male Kunming mice)[1] Dosage: 25, 50 or 100 mg/kg Administration: Intragastric administration Result: Had the observed antidiabetes activity in mice.
References	[1]. Bu T, et al.α-Glucosidase inhibition and the in vivo hypoglycemic effect of butyl-isobutyl-phthalate derived from the Laminaria japonica rhizoid.Phytother Res. 2010 Nov;24(11):1588-91.

Density	1.1±0.1 g/cm3
Boiling Point	315.7±10.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₂O₄
Molecular Weight	278.344
Flash Point	165.4±8.5 °C
Exact Mass	278.151794
PSA	52.60000
LogP	4.64
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.498

HS Code	2917349000

HS Code	2917349000
Summary	2917349000 other esters of orthophthalic acid。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%