C-DIM 12

Modify Date: 2024-01-02 03:33:15

C-DIM 12 Structure
C-DIM 12 structure
 Common Name C-DIM 12
CAS Number 178946-89-9 Molecular Weight 356.85
Density 1.3±0.1 g/cm3 Boiling Point 585.6±45.0 °C at 760 mmHg
Molecular Formula C23H17ClN2 Melting Point N/A
MSDS USA Flash Point 336.1±14.3 °C

 Use of C-DIM 12


C-DIM12 is a synthetic Nurr1 activaor induces Nurr1 and DA gene expression in cell lines and primary neurons.Target: Nurr1in vitro: C-DIM12 as a modulator of Nurr1 activity that results in inhibition of NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. C-DIM12 Decreases Inflammatory Gene Expression in BV-2 Microglia. C-DIM12 Decreases Expression of NF-κB-Enhanced GFP Expression in Human Embryonic Kidney 293 Reporter Cells.[1] C-DIM12 increases protein levels of exogenously expressed human Nurr1 in transfected neurons.C-DIM12 protects neurons from 6-hydroxydopamine toxicity. [2]

 Names

Name 3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole
Synonym More Synonyms

 C-DIM 12 Biological Activity

Description C-DIM12 is a synthetic Nurr1 activaor induces Nurr1 and DA gene expression in cell lines and primary neurons.Target: Nurr1in vitro: C-DIM12 as a modulator of Nurr1 activity that results in inhibition of NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. C-DIM12 Decreases Inflammatory Gene Expression in BV-2 Microglia. C-DIM12 Decreases Expression of NF-κB-Enhanced GFP Expression in Human Embryonic Kidney 293 Reporter Cells.[1] C-DIM12 increases protein levels of exogenously expressed human Nurr1 in transfected neurons.C-DIM12 protects neurons from 6-hydroxydopamine toxicity. [2]
Related Catalog
References

[1]. De Miranda BR, et al. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34. doi: 10.1124/mol.114.095398. Epub

[2]. Hammond SL, et al. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neurosci Lett. 2015 Oct 21;607:83-9.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 585.6±45.0 °C at 760 mmHg
Molecular Formula C23H17ClN2
Molecular Weight 356.85
Flash Point 336.1±14.3 °C
LogP 6.13
Appearance of Characters white solid
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.747
Storage condition -20℃

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

3,3'-[(4-Chlorophenyl)methylene]bis(1H-indole)
1H-Indole, 3,3'-[(4-chlorophenyl)methylene]bis-
C-DIM12
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Chemsrc provides C-DIM 12(CAS#:178946-89-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of C-DIM 12 are included as well.>> amp version: C-DIM 12

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