Eptapirone
Modify Date: 2024-01-17 01:03:59
Eptapirone structure
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Common Name | Eptapirone | ||
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| CAS Number | 179756-58-2 | Molecular Weight | 345.40 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 519.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C16H23N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 268.2±32.9 °C | |
Use of EptapironeF 11440 is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.Target: 5-HT1AThe affinity of F 11440 for 5-HT1Abinding sites (pKi, 8.33) was higher than that of buspirone (pKi , 7.50), and somewhat lower than that of flesinoxan (pKi , 8.91).In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively). F 11440, shown here to be a potent, selective, high efficacy 5-HT1Areceptor agonist, appears to have the potential to exert marked anxiolytic and antidepressant activity in humans.[1] |
| Name | 4-Methyl-2-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1,2,4-triazinane-3,5-dione |
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| Synonym | More Synonyms |
| Description | F 11440 is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.Target: 5-HT1AThe affinity of F 11440 for 5-HT1Abinding sites (pKi, 8.33) was higher than that of buspirone (pKi , 7.50), and somewhat lower than that of flesinoxan (pKi , 8.91).In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively). F 11440, shown here to be a potent, selective, high efficacy 5-HT1Areceptor agonist, appears to have the potential to exert marked anxiolytic and antidepressant activity in humans.[1] |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 519.9±60.0 °C at 760 mmHg |
| Molecular Formula | C16H23N7O2 |
| Molecular Weight | 345.40 |
| Flash Point | 268.2±32.9 °C |
| LogP | -0.34 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.563 |
| 4-Methyl-2-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-1,2,4-triazinane-3,5-dione |
| 1,2,4-Triazine-3,5(2H,4H)-dione, dihydro-4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]- |
| Eptapirone |
| F 11440 |