(1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid

Modify Date: 2024-02-04 19:39:14

(1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid structure	Common Name	(1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid
	CAS Number	1800017-49-5	Molecular Weight	437.55
	Density	1.4±0.1 g/cm3	Boiling Point	690.9±65.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₇N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	371.6±34.3 °C

Use of (1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid

PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/<3.7/5.0/<4.1, respectively[1].

Name	AZ044
Synonym	More Synonyms

Description	PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/<3.7/5.0/<4.1, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> PI4K
Target	PI4KIIIα:9.0 (pIC50) PI4KIIIβ:6.6 (pIC50) PI3Kα:4.0 (pIC50) PI3Kβ:<3.7 (pIC50) PI3Kγ:5.0 (pIC50) PI3Kδ:<4.1 (pIC50)
References	[1]. Raubo P, et al. Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3189-93.

Density	1.4±0.1 g/cm3
Boiling Point	690.9±65.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₇N₃O₃S
Molecular Weight	437.55
Flash Point	371.6±34.3 °C
Exact Mass	437.177307
LogP	3.86
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.691
Storage condition	store at -20℃ for one year（Powder）

4-[({6-[1-(Cyclopropylmethyl)-2-oxo-1,2-dihydro-4-pyridinyl]-1,3-benzothiazol-2-yl}amino)methyl]cyclohexanecarboxylic acid

Cyclohexanecarboxylic acid, 4-[[[6-[1-(cyclopropylmethyl)-1,2-dihydro-2-oxo-4-pyridinyl]-2-benzothiazolyl]amino]methyl]-

(1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid

Use of (1r,4r)-4-(((6-(1-(Cyclopropylmethyl)-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)methyl)cyclohexane-1-carboxylicacid

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