VU 0650786

Modify Date: 2024-01-10 15:06:32

VU 0650786 Structure
VU 0650786 structure
Common Name VU 0650786
CAS Number 1809085-30-0 Molecular Weight 387.80
Density N/A Boiling Point N/A
Molecular Formula C18H15ClFN5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VU 0650786


VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1].

 Names

Name VU0650786

 VU 0650786 Biological Activity

Description VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1].
Related Catalog
Target

mGluR3:392 nM (IC50)

References

[1]. Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500.

 Chemical & Physical Properties

Molecular Formula C18H15ClFN5O2
Molecular Weight 387.80
Storage condition 2-8℃
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