DT-061
Modify Date: 2024-01-15 22:00:32
DT-061 structure
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Common Name | DT-061 | ||
|---|---|---|---|---|
| CAS Number | 1809427-19-7 | Molecular Weight | 520.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H23F3N2O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DT-061DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis[1]. |
| Name | DT-061 |
|---|
| Description | DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis[1]. |
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| Related Catalog | |
| Target |
PP2A[1]. |
| In Vivo | DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient[1]. Animal Model: 6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106)[1]. Dosage: 5 mg/kg. Administration: Oral gavage for 4 weeks. Result: Showed activity in inhibiting tumor growth. |
| References |
| Molecular Formula | C25H23F3N2O5S |
|---|---|
| Molecular Weight | 520.52 |
| Storage condition | 2-8℃ |