AR antagonist 1 hydrochloride
Modify Date: 2024-04-03 15:57:10
AR antagonist 1 hydrochloride structure
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Common Name | AR antagonist 1 hydrochloride | ||
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| CAS Number | 1818885-55-0 | Molecular Weight | 315.24 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H20Cl2N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AR antagonist 1 hydrochlorideAR antagonist 1 (compound 29) hydrochloride is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020)[1]. |
| Name | AR antagonist 1 hydrochloride |
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| Description | AR antagonist 1 (compound 29) hydrochloride is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020)[1]. |
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| Related Catalog | |
| In Vitro | AR antagonist 1 (compound 29) hydrochloride 是 ARD-266 靶连接酶的配体。 ARD-266 是一种高效的基于 VHL E3 连接酶的雄激素受体 (AR) PROTAC 降解剂[1]。 AR antagonist 1 与其 E3 连接酶复合物具有微摩尔结合亲和力，可成功用于设计高效的 PROTAC 降解剂[1]。 PROTAC 包含两个不同的配体，通过一个接头连接； 一种是E3泛素连接酶的配体，另一种是靶蛋白的配体。 PROTACs 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。 |
| References |
| Molecular Formula | C15H20Cl2N2O |
|---|---|
| Molecular Weight | 315.24 |