PIM-447 dihydrochloride

Modify Date: 2024-04-05 19:33:07

PIM-447 dihydrochloride structure	Common Name	PIM-447 dihydrochloride
	CAS Number	1820565-69-2	Molecular Weight	513.383
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₅Cl₂F₃N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PIM-447 dihydrochloride

PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.

Name	N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-3-pyridinyl}-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide dihydrochloride
Synonym	More Synonyms

Description	PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> Pim Research Areas >> Cancer
References	[1]. Paíno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20. [2]. Burger MT et al. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. J Med Chem. 2015 Nov 12;58(21):8373-86. [3]. Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Oncotarget. 2016 Aug 20

Description

PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.

Related Catalog

Signaling Pathways >> JAK/STAT Signaling >> Pim

Research Areas >> Cancer

References

2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-, hydrochloride (1:2)

N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-3-pyridinyl}-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide dihydrochloride

PIM-447 dihydrochloride

PIM-447 (dihydrochloride)

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Price: $407/10mM*1mLinDMSO