(3S,4S)-PF-06459988

Modify Date: 2024-01-14 14:19:59

(3S,4S)-PF-06459988 Structure
(3S,4S)-PF-06459988 structure
 Common Name (3S,4S)-PF-06459988
CAS Number 1858291-14-1 Molecular Weight 431.88
Density N/A Boiling Point N/A
Molecular Formula C19H22ClN7O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (3S,4S)-PF-06459988


(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling[1].

 Names

Name (3S,4S)-PF-06459988

 (3S,4S)-PF-06459988 Biological Activity

Description (3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling[1].
Related Catalog
Target

EGFR[1]

References

[1]. Cheng, H., et al. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. Journal of Medicinal Chemistry, 59(5), 2005–2024.

 Chemical & Physical Properties

Molecular Formula C19H22ClN7O3
Molecular Weight 431.88
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