A-893
Modify Date: 2024-01-08 15:45:44
A-893 structure
|
Common Name | A-893 | ||
|---|---|---|---|---|
| CAS Number | 1868232-32-9 | Molecular Weight | 577.542 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 790.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C29H38Cl2N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 431.9±32.9 °C | |
Use of A-893A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC50 of 2.8 nM. |
| Name | A-893 |
|---|---|
| Synonym | More Synonyms |
| Description | A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC50 of 2.8 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 2.8 nM (SMYD2)[1]. |
| In Vitro | The ratio of p53K370me1 to overall p53 levels is reduced, as expected, by treatment with either A-893 or AZ505. While this unexpectedly depicts a more robust response with AZ505, further dissection of the data provides clarity into the origin of this. While overall p53 levels are unaffected by A-893, a surprising >3-fold increase is observed with AZ505. Analysis of p53K370me1 levels reveals that inhibitor A-893 exhibited 42% reduction in the methyl mark, while AZ-505 is slightly less effective at 28% reduction[1]. |
| Cell Assay | Human A549 lung carcinoma cells are chosen due to their high SMYD2 expression levels and wild-type p53 status. After 18 h of treatment with 10 μM of compound (e.g. A-893), changes in p53K370me1 are measured along with changes to overall p53 levels[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 790.6±60.0 °C at 760 mmHg |
| Molecular Formula | C29H38Cl2N4O4 |
| Molecular Weight | 577.542 |
| Flash Point | 431.9±32.9 °C |
| Exact Mass | 576.226990 |
| LogP | 3.13 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Index of Refraction | 1.623 |
| N-Cyclohexyl-N-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[(2R)-2-hydroxy-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-β-alaninamide |
| Propanamide, N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[(2R)-2-(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-8-yl)-2-hydroxyethyl]amino]ethyl]- |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: T-26c
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: A-893
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: A-893
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
Get all suppliers and price by the below link: