JK-273

Modify Date: 2024-01-15 14:07:40

JK-273 Structure
JK-273 structure
 Common Name JK-273
CAS Number 187723-38-2 Molecular Weight 335.790
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C18H14ClN5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JK-273


A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin; inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity), causes cell cycle arrest at S phase and induces apoptosis.

 Names

Name 6-(4-Aminophenyl)-N-(3-chlorophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine
Synonym More Synonyms

 JK-273 Biological Activity

Description A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin; inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity), causes cell cycle arrest at S phase and induces apoptosis.
References References 1. Lee J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):977-80. 2. Lu TN, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):355-360. View Related Products by Target Integrin

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C18H14ClN5
Molecular Weight 335.790
Exact Mass 335.093781
LogP 4.70
Index of Refraction 1.777

 Synonyms

6-(4-Aminophenyl)-N-(3-chlorophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-(4-aminophenyl)-N-(3-chlorophenyl)-
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Chemsrc provides JK-273(CAS#:187723-38-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of JK-273 are included as well.>> amp version: JK-273

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