187723-38-2
187723-38-2 structure
- Name: JK-273
- Chemical Name: 6-(4-Aminophenyl)-N-(3-chlorophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine
- CAS Number: 187723-38-2
- Molecular Formula: C18H14ClN5
- Molecular Weight: 335.790
- Create Date: 2020-01-11 19:18:42
- Modify Date: 2024-01-15 14:07:40
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A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin; inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity), causes cell cycle arrest at S phase and induces apoptosis.
| Name | 6-(4-Aminophenyl)-N-(3-chlorophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine |
|---|---|
| Synonyms |
6-(4-Aminophenyl)-N-(3-chlorophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-(4-aminophenyl)-N-(3-chlorophenyl)- |
| Description | A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin; inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity), causes cell cycle arrest at S phase and induces apoptosis. |
|---|---|
| References | References 1. Lee J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):977-80. 2. Lu TN, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):355-360. View Related Products by Target Integrin |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H14ClN5 |
| Molecular Weight | 335.790 |
| Exact Mass | 335.093781 |
| LogP | 4.70 |
| Index of Refraction | 1.777 |