Arachidonoyl serotonin
Arachidonoyl serotonin structure
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Common Name | Arachidonoyl serotonin | ||
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| CAS Number | 187947-37-1 | Molecular Weight | 462.667 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 680.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C30H42N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 365.3±31.5 °C | |
Use of Arachidonoyl serotoninN-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC50=70~100 nM). N-Arachidonoylserotonin is analgesic in rodents [1]. |
| Name | Arachidonoylserotonin |
|---|---|
| Synonym | More Synonyms |
| Description | N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 µM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC50=70~100 nM). N-Arachidonoylserotonin is analgesic in rodents [1]. |
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| Related Catalog | |
| Target |
IC50: 1~12 µM (FAAH), 70~100 nM (TRPV1 channels)[1] |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 680.5±55.0 °C at 760 mmHg |
| Molecular Formula | C30H42N2O2 |
| Molecular Weight | 462.667 |
| Flash Point | 365.3±31.5 °C |
| Exact Mass | 462.324615 |
| PSA | 65.12000 |
| LogP | 7.16 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.574 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Anticonvulsant effects of N-arachidonoyl-serotonin, a dual fatty acid amide hydrolase enzyme and transient receptor potential vanilloid type-1 (TRPV1) channel blocker, on experimental seizures: the roles of cannabinoid CB1 receptors and TRPV1 channels.
Basic Clin Pharmacol Toxicol. 115(4) , 330-4, (2014) Selective blockade of anandamide hydrolysis, through the inhibition of the FAAH enzyme, has anticonvulsant effects, which are mediated by CB1 receptors. Anandamide, however, also activates TRPV1 chann... |
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The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.
Pharmacol. Res. 61 , 537-46, (2010) Given that the pharmacological or genetic inactivation of fatty acid amide hydrolase (FAAH) counteracts pain and inflammation, and on the basis of the established involvement of transient receptor pot... |
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The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats de Novellis, V., et al.
Mol. Pain 17 , 7, (2011)
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| (5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-icosatetraenamide |
| Arachidonoyl serotonin |
| AA-5-HT N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenamide |
| (5Z,8Z,11Z,14Z)-N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14-tetraenamide |
| Arachidonyl serotonin,N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide |
| 5,8,11,14-Eicosatetraenamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-, (5Z,8Z,11Z,14Z)- |
| Arachidonyl serotonin |
| N-Arachidonoylserotonin |