IACS-4619

Modify Date: 2024-09-10 17:55:48

IACS-4619 Structure
IACS-4619 structure
Common Name IACS-4619
CAS Number 1884209-98-6 Molecular Weight 195.266
Density N/A Boiling Point N/A
Molecular Formula C10H17N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IACS-4619


IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.

 Names

Name IACS-4619

 IACS-4619 Biological Activity

Description IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.
References References 1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7. View Related Products by Target DNA Repair Protein

 Chemical & Physical Properties

Molecular Formula C10H17N3O
Molecular Weight 195.266
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