NI 42
Modify Date: 2024-01-06 14:28:47
NI 42 structure
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Common Name | NI 42 | ||
|---|---|---|---|---|
| CAS Number | 1884640-99-6 | Molecular Weight | 353.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H15N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NI 42NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/ 940 nM) with excellent selectivity over nonclass IV BRD proteins[1]. |
| Name | NI-42 |
|---|
| Description | NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/ 940 nM) with excellent selectivity over nonclass IV BRD proteins[1]. |
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| Related Catalog | |
| Target |
BRPF1:7.9 nM (IC50) BRPF2:48 nM (IC50) BRPF3:260 nM (IC50) BRPF1:40 nM (Kd) BRPF2:210 nM (Kd) BRPF3:940 nM (Kd) BRD4 (BD1):4500 nM (IC50) BRD7:82 nM (IC50) BRD9:310 nM (IC50) BRD9:1130 nM (Kd) |
| In Vitro | NI-42 shows IC50s of 82, 310, and 4500 nM for BRD7, BRD9, and BRD4 (BD1), respectively, and has a Kd of 1130 nM for BRD9[1]. |
| References |
| Molecular Formula | C18H15N3O3S |
|---|---|
| Molecular Weight | 353.40 |