Cl-4AS-1
Modify Date: 2024-01-02 12:43:10
Cl-4AS-1 structure
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Common Name | Cl-4AS-1 | ||
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| CAS Number | 188589-66-4 | Molecular Weight | 441.01 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H33ClN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Cl-4AS-1Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2]. |
| Name | N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5α-androst-1-ene-17β-carboxamide |
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| Description | Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2]. |
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| Related Catalog | |
| Target |
IC50: 12 nM (androgen receptor); 6 nM (5α-reductase types I); 10 nM (5α-reductase types II)[1][2] |
| In Vitro | Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells[1]. Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%[1]. |
| In Vivo | Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight[1]. Animal Model: ORX rats[1] Dosage: 10 mg/kg Administration: I.s.; 7 days Result: Effect of Cl-4AS-1 on prostate and seminal vesicle growth. |
| References |
| Molecular Formula | C26H33ClN2O2 |
|---|---|
| Molecular Weight | 441.01 |
| Exact Mass | 440.22300 |
| PSA | 49.41000 |
| LogP | 5.54500 |