KU14R
Modify Date: 2024-01-08 17:53:59
KU14R structure
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Common Name | KU14R | ||
|---|---|---|---|---|
| CAS Number | 189224-48-4 | Molecular Weight | 214.263 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 428.1±34.0 °C at 760 mmHg | |
| Molecular Formula | C13H14N2O | Melting Point | 137-139ºC | |
| MSDS | N/A | Flash Point | 154.4±15.9 °C | |
Use of KU14RKU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.IC50 Value:Target: Insulin ReceptorA new I(3)-R antagonist, KU14R (2 (2-ethyl 2,3-dihydro-2-benzofuranyl)-2-imidazole), which selectively blocks the insulin secretory response to imidazolines. KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by measuring KATP channel activity, plasma membrane potential, cytosolic calcium concentration ([Ca2+]c) and dynamic insulin secretion. In the presence of 10 mmol/l but not of 5 mmol/l glucose, KU14R (30, 100 or 300 micromol/l) was ineffective. KATP channel was blocked by KU14R (IC50 31.9 micromol/l, Hill slope -1.5). KU14R does not act as an antagonist of either efaroxan or S22068 at an imidazoline site in vivo. |
| Name | 2-(2-ethyl-3H-1-benzofuran-2-yl)-1H-imidazole |
|---|---|
| Synonym | More Synonyms |
| Description | KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.IC50 Value:Target: Insulin ReceptorA new I(3)-R antagonist, KU14R (2 (2-ethyl 2,3-dihydro-2-benzofuranyl)-2-imidazole), which selectively blocks the insulin secretory response to imidazolines. KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by measuring KATP channel activity, plasma membrane potential, cytosolic calcium concentration ([Ca2+]c) and dynamic insulin secretion. In the presence of 10 mmol/l but not of 5 mmol/l glucose, KU14R (30, 100 or 300 micromol/l) was ineffective. KATP channel was blocked by KU14R (IC50 31.9 micromol/l, Hill slope -1.5). KU14R does not act as an antagonist of either efaroxan or S22068 at an imidazoline site in vivo. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 428.1±34.0 °C at 760 mmHg |
| Melting Point | 137-139ºC |
| Molecular Formula | C13H14N2O |
| Molecular Weight | 214.263 |
| Flash Point | 154.4±15.9 °C |
| Exact Mass | 214.110611 |
| PSA | 37.91000 |
| LogP | 2.10 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.595 |
| Storage condition | Store at RT |
| cs-1007 |
| 1H-Imidazole, 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)- |
| hms3267m22 |
| ku14r |
| 2-(2-Ethyl-2,3-dihydro-1-benzofuran-2-yl)-1H-imidazole |