PI3K-IN-16
Modify Date: 2024-04-02 14:37:43
PI3K-IN-16 structure
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Common Name | PI3K-IN-16 | ||
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| CAS Number | 1895876-81-9 | Molecular Weight | 467.497 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H26FN3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PI3K-IN-16PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively; exhibits no significant activity on PI3Kα; shows profound pharmacodynamic modulation of AKT phosphorylation, excellent tumour growth inhibition in a mouse PTEN-deficient PC3 prostate tumour xenograft. |
| Name | PI3K-IN-16 |
|---|
| Description | PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively; exhibits no significant activity on PI3Kα; shows profound pharmacodynamic modulation of AKT phosphorylation, excellent tumour growth inhibition in a mouse PTEN-deficient PC3 prostate tumour xenograft. |
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| References | References 1. Barlaam B, et al. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23. View Related Products by Target PI3K |
| Molecular Formula | C25H26FN3O5 |
|---|---|
| Molecular Weight | 467.497 |