PF-06815345

Modify Date: 2024-03-10 19:38:19

PF-06815345 Structure
PF-06815345 structure
Common Name PF-06815345
CAS Number 1900686-46-5 Molecular Weight 598.029
Density 1.5±0.1 g/cm3 Boiling Point 775.4±70.0 °C at 760 mmHg
Molecular Formula C27H29ClFN9O4 Melting Point N/A
MSDS N/A Flash Point 422.7±35.7 °C

 Use of PF-06815345


PF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay; PF-06815345is identified after optimization of the prodrug moiety to maximize intestinal stability achieving liver targeting of the active compound after prodrug turnover by carboxylesterase (CES1). Hypercholesterolemia Phase 1 Discontinued

 Names

Name (1S)-1-{5-[4-(4-{(3-Chloro-2-pyridinyl)[(3R)-3-piperidinyl]carbamoyl}-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-1H-tetrazol-1-yl}ethyl ethyl carbonate
Synonym More Synonyms

 PF-06815345 Biological Activity

Description PF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay; PF-06815345is identified after optimization of the prodrug moiety to maximize intestinal stability achieving liver targeting of the active compound after prodrug turnover by carboxylesterase (CES1). Hypercholesterolemia Phase 1 Discontinued
References References 1. McClure KF, et al. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16218-16222. 2. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3. View Related Products by Target PCSK9 Hypercholesterolemia

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 775.4±70.0 °C at 760 mmHg
Molecular Formula C27H29ClFN9O4
Molecular Weight 598.029
Flash Point 422.7±35.7 °C
Exact Mass 597.201477
LogP 2.13
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.686

 Synonyms

(1S)-1-{5-[4-(4-{(3-Chloro-2-pyridinyl)[(3R)-3-piperidinyl]carbamoyl}-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-1H-tetrazol-1-yl}ethyl ethyl carbonate
Carbonic acid, (1S)-1-[5-[4-[4-[[(3-chloro-2-pyridinyl)-(3R)-3-piperidinylamino]carbonyl]-2-fluorophenyl]-1-methyl-1H-pyrazol-5-yl]-1H-tetrazol-1-yl]ethyl ethyl ester
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