GSK2879552 dihydrochloride
Modify Date: 2024-01-06 15:58:58
GSK2879552 dihydrochloride structure
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Common Name | GSK2879552 dihydrochloride | ||
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| CAS Number | 1902123-72-1 | Molecular Weight | 437.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H30Cl2N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GSK2879552 dihydrochlorideGSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity[1][2]. |
| Name | GSK2879552 dihydrochloride |
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| Description | GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity[1][2]. |
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| Related Catalog | |
| In Vitro | GSK2879552 inhibits KDM1A histone demethylase activity, inducing differentiation of sorafenib-resistant cells and attenuates stemness properties. GSK2879552 depresses the transcription of Wnt antagonists and downregulates β-catenin signaling activity in sorafenib-resistant cells[1]. Cell Viability Assay[2]. Cell Line: 9/28 small cell lung carcinoma (SCLC) lines and 20/29 AML lines. Concentration: 0-10000 nM. Incubation Time: 6 days. Result: Inhibited cell proliferation. RT-PCR[1]. Cell Line: Resistant HCC cells (PLC/PRF/5 and Huh7). Concentration: 0, 1, 2 μM. Incubation Time: 24 h. Result: Displayed reduced mRNA expression levels of stem cell markers, such as Lgr5, Sox9,Nanog and CD90, and elevated mRNA expression levels of differentiation markers Alb and Hnf4. |
| In Vivo | GSK2879552 (1.5 mg/kg, p.o.) treatment exhibits tumor growth inhibition in SCLC xenograft bearing mice[2]. Animal Model: NCI-H526 and NCI-H1417 xenografts[2]. Dosage: 1.5 mg/kg. Administration: PO daily for 25-35 days. Result: There was 57% and 83% tumor growth inhibition (TGI) in NCI-H526 and NCI-H1417 tumor bearing mice respectively. NCI-H510 and NCI-H69 tumor bearing mice also demonstrated partial TGI (38% and 49% respectively) in response to GSK2879552, while no significant TGI was observed for SHP77 bearing mice. |
| References |
| Molecular Formula | C23H30Cl2N2O2 |
|---|---|
| Molecular Weight | 437.40 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: GSK2879552 2HCl
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
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