(+)-Norfenfluramine

Modify Date: 2024-01-08 11:44:44

(+)-Norfenfluramine structure	Common Name	(+)-Norfenfluramine
	CAS Number	19036-73-8	Molecular Weight	203.20400
	Density	1.152g/cm3	Boiling Point	215.2ºC at 760mmHg
	Molecular Formula	C₁₀H₁₂F₃N	Melting Point	N/A
	MSDS	N/A	Flash Point	88.9ºC

Use of (+)-Norfenfluramine

(+)-Norfenfluramine a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). (+)-Norfenfluramine potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+)-Norfenfluramine can be used for the research of primary pulmonary hypertension and valvular heart disease[1].

Name	(s)-1-(3-trifluoromethylphenyl)-2-aminopropane
Synonym	More Synonyms

Description	(+)-Norfenfluramine a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). (+)-Norfenfluramine potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+)-Norfenfluramine can be used for the research of primary pulmonary hypertension and valvular heart disease[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT2B Receptor:11.2 nM (Ki) 5-HT2A Receptor:1516 nM (Ki) 5-HT2C Receptor:324 nM (Ki)
In Vitro	(+)-Norfenfluramine (1 nM to 100 μM) contracts arteries with a dramatic decrease in threshold (aorta and mesenteric resistance artery) in rats[1]. (+)-Norfenfluramine (1 and 10 μM, 3 min) induces contraction in aorta from tissues of normotensive and hypertensive rats[1]. (+)-Norfenfluramine (0-10 μM, 3 min) induces 5-HT release from rat hippocampal synaptosomes by Ca2+-dependent way [2].
In Vivo	(+)-Norfenfluramine (1-300 μg/kg, i.v.) induces pressor response in conscious SHAM and DOCA-salt rats[1]. (+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats[3]. Animal Model: Conscious SHAM and DOCA-salt rats[1]. Dosage: 1-300 μg/kg Administration: Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals. Result: Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19).
References	[1]. Wei Ni, et al. The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321(2):485-91. [2]. M Gobbi, et al. In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):323-7. [3]. R Invernizzi, et al. Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain? Br J Pharmacol. 1982 Mar;75(3):525-30.

Density	1.152g/cm3
Boiling Point	215.2ºC at 760mmHg
Molecular Formula	C₁₀H₁₂F₃N
Molecular Weight	203.20400
Flash Point	88.9ºC
Exact Mass	203.09200
PSA	26.02000
LogP	3.29540
Vapour Pressure	0.15mmHg at 25°C
Index of Refraction	1.467

HS Code	2921499090

N/A

CAS#:213202-12-1

~89%

(+)-Norfenfluramine

CAS#:19036-73-8

Literature: Alfa Chemicals Italiana S.r.l. Patent: EP875498 A2, 1998 ;

N/A

CAS#:213202-12-1

Palladium

CAS#:7440-05-3

~91%

(+)-Norfenfluramine

CAS#:19036-73-8

Literature: Alfa Chemicals Italiana S.p.A. Patent: US5808156 A1, 1998 ;

(S),(S)-N-(1-ph...

CAS#:58225-71-1

(+)-Norfenfluramine

CAS#:19036-73-8

Literature: Alfa Chemicals Italiana S.r.l. Patent: EP875498 A2, 1998 ;

(S),(S)-N-(1-ph...

CAS#:58225-71-1

Palladium

CAS#:7440-05-3

(+)-Norfenfluramine

CAS#:19036-73-8

Literature: Alfa Chemicals Italiana S.p.A. Patent: US5808156 A1, 1998 ;

(S)-2-(1-(3-(tr...

CAS#:213682-62-3

(+)-Norfenfluramine

CAS#:19036-73-8

Literature: Fogagnolo, Marco; Giovannini, Pier Paolo; Guerrini, Alessandra; Medici, Alessandro; Pedrini, Paola; Colombi, Nicola Tetrahedron Asymmetry, 1998 , vol. 9, # 13 p. 2317 - 2327

3-(Trifluoromet...

CAS#:21906-39-8

(+)-Norfenfluramine

CAS#:19036-73-8

Literature: Fogagnolo, Marco; Giovannini, Pier Paolo; Guerrini, Alessandra; Medici, Alessandro; Pedrini, Paola; Colombi, Nicola Tetrahedron Asymmetry, 1998 , vol. 9, # 13 p. 2317 - 2327

N/A

CAS#:135561-75-0

(+)-Norfenfluramine

CAS#:19036-73-8

Literature: Fogagnolo, Marco; Giovannini, Pier Paolo; Guerrini, Alessandra; Medici, Alessandro; Pedrini, Paola; Colombi, Nicola Tetrahedron Asymmetry, 1998 , vol. 9, # 13 p. 2317 - 2327

1-[3-(trifluoro...

CAS#:135561-78-3

(+)-Norfenfluramine

CAS#:19036-73-8

Literature: Fogagnolo, Marco; Giovannini, Pier Paolo; Guerrini, Alessandra; Medici, Alessandro; Pedrini, Paola; Colombi, Nicola Tetrahedron Asymmetry, 1998 , vol. 9, # 13 p. 2317 - 2327

Precursor 4
CAS#:7440-05-3 Palladium CAS#:58225-71-1 (S),(S)-N-(1-ph... CAS#:21906-39-8 3-(Trifluoromet... CAS#:135561-78-3 1-[3-(trifluoro...
DownStream 0

HS Code	2921499090
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%