NSC232003
Modify Date: 2024-01-30 20:26:08
NSC232003 structure
|
Common Name | NSC232003 | ||
|---|---|---|---|---|
| CAS Number | 1905453-18-0 | Molecular Weight | 169.14 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H7N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NSC232003NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level. |
| Name | NSC232003 |
|---|
| Description | NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level. |
|---|---|
| Related Catalog | |
| Target |
UHRF1[1] |
| In Vitro | NSC232003, a uracil derivative freely available by the NCI/DTP repository, provides a versatile lead for developing highly potent and cell-permeable UHRF1 inhibitors that will enable dissection of DNA methylation inheritance. NSC232003 is indeed an effective DNA methylation inhibitor and indicate that this particular nucleotide scaffold could provide a versatile basis for the design of potent UHRF1 inhibitors. NSC232003 is predicted to be partially deprotonated at pH 7, as the pKa of the more acidic imide nitrogen of the pyrimidine ring is a value of 7.6 in NSC232003. The DNMT1/UHRF1 interactions are significantly reduced after 4 h of incubation of U251 glioma cells with the most potent compound NSC232003, showing a 50% interaction inhibition at 15 μM as well as induction of global DNA cytosine demethylation as measured by ELISA[1]. |
| References |
| Molecular Formula | C6H7N3O3 |
|---|---|
| Molecular Weight | 169.14 |
| Storage condition | 2-8℃ |