MONIRO-1

Modify Date: 2024-01-14 00:53:47

MONIRO-1 Structure
MONIRO-1 structure
Common Name MONIRO-1
CAS Number 1909225-94-0 Molecular Weight 458.91
Density N/A Boiling Point N/A
Molecular Formula C23H24ClFN4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MONIRO-1


MONIRO-1 is a T-type and N-type calcium channel blocker with IC50 values of 34, 3.3, 1.7 and 7.2 µM against hCav2.2, hCav3.1, hCav3.2 and hCav3.3, respectively[1].

 Names

Name MONIRO-1

 MONIRO-1 Biological Activity

Description MONIRO-1 is a T-type and N-type calcium channel blocker with IC50 values of 34, 3.3, 1.7 and 7.2 µM against hCav2.2, hCav3.1, hCav3.2 and hCav3.3, respectively[1].
Related Catalog
Target

Cav3.1:3.3 μM (IC50)

Cav3.2:1.7 μM (IC50)

Cav3.3:7.2 μM (IC50)

Cav2.2:34 μM (IC50)

References

[1]. McArthur JR, et al. Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. Br J Pharmacol. 2018 Jun;175(12):2284-2295.

 Chemical & Physical Properties

Molecular Formula C23H24ClFN4O3
Molecular Weight 458.91
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