mPGES1-IN-16

Modify Date: 2024-09-17 16:19:18

mPGES1-IN-16 Structure
mPGES1-IN-16 structure
Common Name mPGES1-IN-16
CAS Number 1915003-93-8 Molecular Weight 485.628
Density N/A Boiling Point N/A
Molecular Formula C30H35N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of mPGES1-IN-16


mPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM; displays no activity against a panel of 35 receptors, ion channels, and hERG; shows IC50/IC80 of 6 nM/24 nM for inhibition of PGE2 formation in vitro in LPS-stimulated human whole blood (HWB); orally bioavailable in vivo.

 Names

Name mPGES1-IN-16

 mPGES1-IN-16 Biological Activity

Description mPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM; displays no activity against a panel of 35 receptors, ion channels, and hERG; shows IC50/IC80 of 6 nM/24 nM for inhibition of PGE2 formation in vitro in LPS-stimulated human whole blood (HWB); orally bioavailable in vivo.
References References 1. Partridge KM, et al. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1478-1483. View Related Products by Target PGE synthase

 Chemical & Physical Properties

Molecular Formula C30H35N3O3
Molecular Weight 485.628
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