1915003-93-8
1915003-93-8 structure
- Name: mPGES1-IN-16
- Chemical Name: mPGES1-IN-16
- CAS Number: 1915003-93-8
- Molecular Formula: C30H35N3O3
- Molecular Weight: 485.628
- Create Date: 2020-01-12 16:54:23
- Modify Date: 2024-09-17 16:19:18
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mPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM; displays no activity against a panel of 35 receptors, ion channels, and hERG; shows IC50/IC80 of 6 nM/24 nM for inhibition of PGE2 formation in vitro in LPS-stimulated human whole blood (HWB); orally bioavailable in vivo.
| Name | mPGES1-IN-16 |
|---|
| Description | mPGES1-IN-16 is a potent and selective mPGES-1 inhibitor with IC50 of 1 nM; displays no activity against a panel of 35 receptors, ion channels, and hERG; shows IC50/IC80 of 6 nM/24 nM for inhibition of PGE2 formation in vitro in LPS-stimulated human whole blood (HWB); orally bioavailable in vivo. |
|---|---|
| References | References 1. Partridge KM, et al. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1478-1483. View Related Products by Target PGE synthase |
| Molecular Formula | C30H35N3O3 |
|---|---|
| Molecular Weight | 485.628 |