SPT-IN-1
Modify Date: 2024-01-16 13:51:00
SPT-IN-1 structure
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Common Name | SPT-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1933533-18-6 | Molecular Weight | 364.44 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H24N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SPT-IN-1SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1]. |
| Name | SPT Imidazopyridine 1 |
|---|---|
| Synonym | More Synonyms |
| Description | SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1]. |
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| Related Catalog | |
| Target |
IC50: 5.19 nM (hSPT1)[1] |
| In Vitro | SPT-IN-1 (compound 1) exhibits a dose-dependent inhibition of C14-serine incorporation into ceramide in MCF-7 cells, with EC50 of 0.98 μM[1]. |
| In Vivo | SPT-IN-1 (compound 1) (Sprague Dawley rats, 0-60 mg/kg, Orally, twice daily for 7 days) dose-dependently reduces plasma ceramides, reduces triglycerides and raises HDL in cholesterol/cholic acid fed rats[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H24N2O3 |
| Molecular Weight | 364.44 |
| Exact Mass | 364.178680 |
| LogP | 3.78 |
| Index of Refraction | 1.603 |
| MFCD31579859 |
| [4-(6-Heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl]acetic acid |
| Benzeneacetic acid, 4-[6-(1-oxoheptyl)imidazo[1,2-a]pyridin-8-yl]- |
| 4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid |