E3 ligase Ligand 1
Modify Date: 2024-01-03 13:52:10
E3 ligase Ligand 1 structure
|
Common Name | E3 ligase Ligand 1 | ||
|---|---|---|---|---|
| CAS Number | 1948273-03-7 | Molecular Weight | 481.05 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H33ClN4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of E3 ligase Ligand 1E3 ligase Ligand 1 is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology. |
| Name | E3 ligase Ligand 1 |
|---|
| Description | E3 ligase Ligand 1 is a Ligand for E3 Ligase extracted from patent WO/2017/030814A1 compound example 202, used in PROTAC technology. |
|---|---|
| Related Catalog | |
| Target |
Ligand for E3 Ligase[1] |
| In Vitro | E3 ligase Ligand 1 is a VHL E3 ligase-binding ligand[1]. E3 ligase Ligand 1 is used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC. ARV-771, a small-molecule pan-BET degrader based on proteolysis-targeting chimera (PROTAC) technology, demonstrates dramatically improved efficacy in cellular models of castration-resistant prostate cancer (CRPC) as compared with BET inhibition[2]. |
| References |
[1]. WO/2017/030814A1 |
| Molecular Formula | C23H33ClN4O3S |
|---|---|
| Molecular Weight | 481.05 |
| Storage condition | 2-8℃ |