25S-Inokosterone

Modify Date: 2024-01-06 12:21:51

25S-Inokosterone Structure
25S-Inokosterone structure
Common Name 25S-Inokosterone
CAS Number 19595-18-7 Molecular Weight 480.63400
Density N/A Boiling Point N/A
Molecular Formula C27H44O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 25S-Inokosterone


25S-Inokosterone is a phytoecdysone in the roots of two same species of A. bidentata Blume and A. japonica Nakai, and two different species of C. capitata Moq and C. officinalis Kuan. 25S-Inokosterone has the potential for the LPS-induced acute kidney injury research[1][2].

 Names

Name inokosterone
Synonym More Synonyms

 25S-Inokosterone Biological Activity

Description 25S-Inokosterone is a phytoecdysone in the roots of two same species of A. bidentata Blume and A. japonica Nakai, and two different species of C. capitata Moq and C. officinalis Kuan. 25S-Inokosterone has the potential for the LPS-induced acute kidney injury research[1][2].
Related Catalog
In Vitro 25S-Inokosterone (10 μM) significantly promotes the proliferation of LPS-induced NRK52e cells (1.0 μg/mL LPS). 25S-Inokosterone significantly reduces the rate of NRK52e cells apoptosis[1]. 25S-Inokosterone shows weak inhibitory activity for thymus and activation-regulated chemokine expression levels in TNF-α plus IFN-γ induced HaCaT cells. 25S-Inokosterone exhibits the most potent inhibition (80-95% at 200 µg/mL) against TNF-α expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells[3].
References

[1]. Shengchao Wang, et al. Raw and salt-processed Achyranthes bidentata attenuate LPS-induced acute kidney injury by inhibiting ROS and apoptosis via an estrogen-like pathway. Biomed Pharmacother

[2]. Bing Tian Zhao, et al. High performance liquid chromatography used for quality control of Achyranthis Radix. Arch Pharm Res. 2012 Aug;35(8):1449-55.

[3]. K. Kim, et al.Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity. J Appl Biol Chem (2015) 58(1), 13-19.

 Chemical & Physical Properties

Molecular Formula C27H44O7
Molecular Weight 480.63400
Exact Mass 480.30900
PSA 138.45000
LogP 1.71150

 Synonyms

25S-Inokosterone
Inokosteron
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