Mepolizumab

Modify Date: 2024-01-13 12:50:03

Mepolizumab Structure
Mepolizumab structure
Common Name Mepolizumab
CAS Number 196078-29-2 Molecular Weight 762.96600
Density N/A Boiling Point N/A
Molecular Formula C42H66O12 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mepolizumab


Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma[1][2].

 Names

Name (2S,3S,4S,5R,6R)-6-[[(4aR,6aR,6bS,8aS,14aR,14bR)-8a-carboxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,13,14,14a-tetradecahydropicen-3-yl]oxy]-3,5-dihydroxy-4-[(1R,2R,3S,4R)-2,3,4-trihydroxycyclohexyl]oxyoxane-2-carboxylic acid
Synonym More Synonyms

 Mepolizumab Biological Activity

Description Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma[1][2].
Related Catalog
References

[1]. Tim Harrison, et al. Real-world mepolizumab in the prospective severe asthma REALITI-A study: initial analysis. Eur Respir J. 2020 Oct 15;56(4):2000151.

[2]. Ian D Pavord, From DREAM to REALITI-A and beyond: Mepolizumab for the treatment of eosinophil-driven diseases. Allergy. 2022 Mar;77(3):778-797.

 Chemical & Physical Properties

Molecular Formula C42H66O12
Molecular Weight 762.96600
Exact Mass 762.45500
PSA 203.44000
LogP 4.56360

 Synonyms

Mepolizumab
Bosatria