CB-03-01

Modify Date: 2024-01-02 22:15:36

CB-03-01 structure	Common Name	CB-03-01
	CAS Number	19608-29-8	Molecular Weight	402.524
	Density	1.2±0.1 g/cm3	Boiling Point	538.9±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₃₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	179.3±23.6 °C

Use of CB-03-01

Cortexolone 17 alpha-propionate(CB-03-01) is a new topical and peripherally selective androgen antagonist. IC50 value:Target: Androgen ReceptorCortexolone 17 alpha-propionate (CB-03-01) is a new potent topical antiandrogen potentially useful in acne vulgaris. CB-03-01 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.

Name	21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione
Synonym	More Synonyms

Description	Cortexolone 17 alpha-propionate(CB-03-01) is a new topical and peripherally selective androgen antagonist. IC50 value:Target: Androgen ReceptorCortexolone 17 alpha-propionate (CB-03-01) is a new potent topical antiandrogen potentially useful in acne vulgaris. CB-03-01 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.
Related Catalog	Signaling Pathways >> Others >> Androgen Receptor Research Areas >> Endocrinology
References	[1]. Trifu V, et al. Cortexolone 17α-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0·05% cream. Br J Dermatol. 2011 Jul;165(1):177-83. [2]. Celasco G, et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung. 2004;54(12):881-6.

Description

Related Catalog

Signaling Pathways >> Others >> Androgen Receptor

Research Areas >> Endocrinology

References

[1]. Trifu V, et al. Cortexolone 17α-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0·05% cream. Br J Dermatol. 2011 Jul;165(1):177-83.

[2]. Celasco G, et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung. 2004;54(12):881-6.

Density	1.2±0.1 g/cm3
Boiling Point	538.9±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₃₄O₅
Molecular Weight	402.524
Flash Point	179.3±23.6 °C
Exact Mass	402.240631
PSA	80.67000
LogP	3.76
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.555

cortexolone 17α-propionate

[(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate

Pregn-4-ene-3,20-dione, 21-hydroxy-17-(1-oxopropoxy)-

21-Hydroxy-3,20-dioxopregn-4-en-17-yl propionate

CB-03-01

Cortexolone 17 alpha-propionate

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Cortexolone17alpha-propionate
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: CB-03-01
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: CB-03-01
Price: $400.0/100mg $700.0/250mg $1200.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 17 ALPHA-PROPIONATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: $119/10mM*1mLinDMSO

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CB-03-01

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