GAP 26 trifluoroacetate salt

Modify Date: 2024-01-05 11:27:56

GAP 26 trifluoroacetate salt structure	Common Name	GAP 26 trifluoroacetate salt
	CAS Number	197250-15-0	Molecular Weight	1550.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₇₀H₁₀₆N₁₉O₁₉S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GAP 26 trifluoroacetate salt

Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.

Name	Gap 26
Synonym	More Synonyms

Description	Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Gap Junction Protein Research Areas >> Cardiovascular Disease Peptides
Target	Gap Junction Protein[1]
In Vitro	Gap 26 is corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker. Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC50 of 28.4 ± 3.4 μM[1]. Gap 26 abolishes the inositol-1,4,5-trisphosphate (InsP3)-triggered ATP response and reduces the ATP release, but has no effect on gap junctional coupling[2].
References	[1]. Chaytor AT, et al. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol. 1997 Aug 15;503 ( Pt 1):99-110. [2]. Braet K, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33(1):37-48.

Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg

M.W. 1550.78 C70H107N19O19S

VCYDKSFPISHVR

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