Debutyldronedarone hydrochloride

Modify Date: 2024-01-14 10:13:51

Debutyldronedarone hydrochloride Structure
Debutyldronedarone hydrochloride structure
 Common Name Debutyldronedarone hydrochloride
CAS Number 197431-02-0 Molecular Weight 537.11100
Density N/A Boiling Point N/A
Molecular Formula C27H37ClN2O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Debutyldronedarone hydrochloride


Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1].

 Names

Name Desbutyl Dronedarone Hydrochloride
Synonym More Synonyms

 Debutyldronedarone hydrochloride Biological Activity

Description Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1].
Related Catalog
Target

TRα1/TRβ1[1]

References

[1]. Van Beeren HC, et al. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. Endocrinology. 2003 Feb;144(2):552-8.

 Chemical & Physical Properties

Molecular Formula C27H37ClN2O5S
Molecular Weight 537.11100
Exact Mass 536.21100
PSA 106.02000
LogP 7.88320

 Safety Information

Hazard Codes Xi

 Synonyms

N-[2-butyl-3-[4-[3-(butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide,hydrochloride
Dronedarone Impurity 6
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