Oxothiazolidinecarboxylic acid

Modify Date: 2024-01-02 14:47:47

Oxothiazolidinecarboxylic acid structure	Common Name	Oxothiazolidinecarboxylic acid
	CAS Number	19771-63-2	Molecular Weight	147.152
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₄H₅NO₃S	Melting Point	174 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Oxothiazolidinecarboxylic acid

Oxothiazolidinecarboxylic acid, an antioxidant, is a prodrug of cysteine that is inert until metabolized to cysteine intracellulary, thus stimulating glutathione synthesis[1].

Name	(4R)-2-oxo-1,3-thiazolidine-4-carboxylic acid
Synonym	More Synonyms

Description	Oxothiazolidinecarboxylic acid, an antioxidant, is a prodrug of cysteine that is inert until metabolized to cysteine intracellulary, thus stimulating glutathione synthesis[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	Oxothiazolidinecarboxylic acid treatment attenuates plantaris atrophy, restored glutathione levels, and increased catalase, Cu/Zn-SOD1, and Mn-SOD2 mRNA expression, but did not reduce other markers of oxidant stress or levels of these catabolic factors[1]. Animal Model: Male Sprague-Dawley rats (200-250 g, n= 6-7 rats/group)[1]. Dosage: 0.35% (w/v). Administration: Added to their diets at a concentration of 0.35% (w/v) for the final 12 wk. Result: Increased fiber CSAs compared to the non-supplemented, alcohol-fed group.
References	[1]. Jeffrey S Otis, et al. Procysteine Stimulates Expression of Key Anabolic Factors and Reduces Plantaris Atrophy in Alcohol-Fed Rats. Alcohol Clin Exp Res. 2009 Aug;33(8):1450-9.

Density	1.6±0.1 g/cm3
Melting Point	174 °C (dec.)(lit.)
Molecular Formula	C₄H₅NO₃S
Molecular Weight	147.152
Exact Mass	146.999008
PSA	91.70000
LogP	-1.11
Index of Refraction	1.595

Oxothiazolidinecarboxylic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ5426650

CHEMICAL NAME :: 4-Thiazolidinecarboxylic acid, 2-oxo-, (R)-

CAS REGISTRY NUMBER :: 19771-63-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H5-N-O3-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 12,109,1993

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,164,1992

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,164,1992

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	XJ5426650
HS Code	2934999090

L-Cysteine hydr...

CAS#:52-89-1

Phenyl chloroformate

CAS#:1885-14-9

~97%

Oxothiazolidine...

CAS#:19771-63-2

Literature: Seki, Masahiko; Hatsuda, Masanori; Mori, Yoshikazu; Yoshida, Shin-Ichi; Yamada, Shin-Ichi; Shimizu, Toshiaki Chemistry - A European Journal, 2004 , vol. 10, # 23 p. 6102 - 6110

L-cysteine

CAS#:52-90-4

Triphosgene

CAS#:32315-10-9

~74%

Oxothiazolidine...

CAS#:19771-63-2

Literature: Falb; Nudelman; Hassner Synthetic Communications, 1993 , vol. 23, # 20 p. 2839 - 2844

phosgene

CAS#:75-44-5

L-cysteine

CAS#:52-90-4

Oxothiazolidine...

CAS#:19771-63-2

Literature: Bulletin of the Chemical Society of Japan, , vol. 37, # 2 p. 242 - 244

Methyl (4R)-2-o...

CAS#:127761-77-7

Oxothiazolidine...

CAS#:19771-63-2

Literature: Journal of Organic Chemistry, , vol. 57, # 20 p. 5292 - 5300

L-cysteine

CAS#:52-90-4

Oxothiazolidine...

CAS#:19771-63-2

Literature: EP1462444 A1, ; Page 12 ;

Precursor 6
CAS#:52-89-1 L-Cysteine hydr... CAS#:1885-14-9 Phenyl chloroformate CAS#:52-90-4 L-cysteine CAS#:32315-10-9 Triphosgene
CAS#:75-44-5 phosgene CAS#:127761-77-7 Methyl (4R)-2-o...
DownStream 1
CAS#:127761-77-7 Methyl (4R)-2-o...

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Ventilator-associated pneumonia (VAP) is an important cause of morbidity and mortality in critical care settings. Acinetobacter has become a leading cause of VAP. In particular, the appearance and spr...

L-2-Oxothiazolidine-4-carboxylic Acid

2-oxothiazolidine-4(R)-carboxylic acid

4-Thiazolidinecarboxylic acid, 2-oxo-, (4R)-

4-Thiazolidinecarboxylic acid,2-oxo-,(R)-[]

OTCA

L-2-Oxothiazolidine-4-carboxylate

(4R)-2-Oxothiazolidine-4-carboxylic acid

(R)-(−)-2-Oxothiazolidine-4-carboxylic acid L-(−)-2-Oxothiazolidine-4-carboxylic acid

L-2-Oxo-4-thiazolidinecarboxylic acid

(R)-2-oxothiazolidine-4-carboxylic acid

L-(−)-2-Oxothiazolidine-4-carboxylic acid

(4R)-2-Oxo-1,3-thiazolidine-4-carboxylic acid

(−)-2-Oxo-4-thiazolidinecarboxylic acid

MFCD00066092

Procysteine

Oxothiazolidine carboxylate,L

(4R)-2-oxo-4-thiazolidine-carboxylic acid

4-Thiazolecarboxylic acid, 4,5-dihydro-2-hydroxy-, (4R)-

(4R)-2-Hydroxy-4,5-dihydro-1,3-thiazole-4-carboxylic acid

L-2-Thiazolidinone-4-carboxylic Acid

2-Oxothiazolidine-4-carboxylate,L

(R)-(−)-2-Oxothiazolidine-4-carboxylic acid

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China
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