vincanol

Modify Date: 2024-01-19 19:20:48

vincanol structure	Common Name	vincanol
	CAS Number	19877-89-5	Molecular Weight	296.40700
	Density	1.35 g/cm3	Boiling Point	484.4ºC at 760 mmHg
	Molecular Formula	C₁₉H₂₄N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	246.8ºC

Use of vincanol

Vincanol ((-)-Isoeburnamine) is a blocker of voltage-gated Na+ channels. Vincanol blocks Na+ currents with an IC50 value of 40 μM. Vincanol has neuroprotective effect[1].

Name	vincanol
Synonym	More Synonyms

Description	Vincanol ((-)-Isoeburnamine) is a blocker of voltage-gated Na+ channels. Vincanol blocks Na+ currents with an IC50 value of 40 μM. Vincanol has neuroprotective effect[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
References	[1]. Erdo SA, et al. Vincamine and vincanol are potent blockers of voltage-gated Na+ channels. Eur J Pharmacol. 1996 Oct 24;314(1-2):69-73.

Density	1.35 g/cm3
Boiling Point	484.4ºC at 760 mmHg
Molecular Formula	C₁₉H₂₄N₂O
Molecular Weight	296.40700
Flash Point	246.8ºC
Exact Mass	296.18900
PSA	28.40000
LogP	3.56320
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.719

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JW4794332

CHEMICAL NAME :: Eburnamenin-14-ol, 14,15-dihydro-, (3-alpha,14-alpha,16-alpha)-

CAS REGISTRY NUMBER :: 19877-89-5

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H24-N2-O

MOLECULAR WEIGHT :: 296.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2319362

14,15-dihydro-eburnamenin-14-ol

14-Doxylstearic acid

14-DOXYL-octadecanoic acid

epi-eburnamine

vincanol

Use of vincanol

Names

vincanol Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms