Gymnestrogenin
Modify Date: 2024-01-09 08:32:22
Gymnestrogenin structure
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Common Name | Gymnestrogenin | ||
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| CAS Number | 19942-02-0 | Molecular Weight | 490.71500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H50O5 | Melting Point | 288-289 °C | |
| MSDS | N/A | Flash Point | N/A | |
Use of GymnestrogeninGymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br[1]. Gymnestrogenin is a LXR antagonist with IC50s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression[2]. |
| Name | (3β,16β,21β)-olean-12-ene-3,16,21,23,28-pentol |
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| Synonym | More Synonyms |
| Description | Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br[1]. Gymnestrogenin is a LXR antagonist with IC50s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression[2]. |
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| Related Catalog | |
| Target |
IC50: 2.5 μM (LXRα) and 1.4 μM (LXRβ)[2] |
| In Vitro | Gymnestrogenin, reducing the expression of SREBP1c and ABCA1 in vitro, is able to decrease lipid accumulation in HepG2 cells[2]. |
| References |
| Melting Point | 288-289 °C |
|---|---|
| Molecular Formula | C30H50O5 |
| Molecular Weight | 490.71500 |
| Exact Mass | 490.36600 |
| PSA | 101.15000 |
| LogP | 4.05530 |
| Gymnestrogenin |
| (3S,4aS,5S,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-4a,9-Bis-hydroxymethyl-2,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydro-picene-3,5,10-triol |
| gymnestrogenin |
| 3β,16β,21β,23,28-pentahydroxyolean-12-ene |