Stattic

Modify Date: 2024-01-04 14:34:20

Stattic Structure
Stattic structure
Common Name Stattic
CAS Number 19983-44-9 Molecular Weight 211.195
Density 1.6±0.1 g/cm3 Boiling Point 461.1±45.0 °C at 760 mmHg
Molecular Formula C8H5NO4S Melting Point 184ºC
MSDS USA Flash Point 232.6±28.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Stattic


Stattic is a potent inhibitor of STAT3 activation and dimerization.

 Names

Name 6-nitro-1-benzothiophene 1,1-dioxide
Synonym More Synonyms

 Stattic Biological Activity

Description Stattic is a potent inhibitor of STAT3 activation and dimerization.
Related Catalog
Target

STAT3

In Vitro Stattic inhibits STAT3 phosphorylation (Y705) in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines at a higher concenration (20 μM). Stattic selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in both ALDH+ and CD44+/CD24+ subpopulations of Panc-1 and HPAC. Stattic inhibita STAT3 downstream targets in ALDH+ and CD44+/CD24+ subpopulations of pancreatic cancer cells[1]. Stattic reduces the LPS-induced expression of ICAM-1 and VCAM-1, and STAT3 phosphorylation[2].
Cell Assay Pancreatic cancer stem-like cells (3,000/well in 96-well plates) are incubated with desired concentrations of compounds in triplicate at 37˚C for 72 h. MTT viability assays are done and the absorbance is read at 595 nm.
References

[1]. Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12.

[2]. Cho YS, et al. Inhibition of STAT3 phosphorylation by sulforaphane reduces adhesion molecule expression in vascular endothelial cell. Can J Physiol Pharmacol. 2015 Nov 18:1-7.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 461.1±45.0 °C at 760 mmHg
Melting Point 184ºC
Molecular Formula C8H5NO4S
Molecular Weight 211.195
Flash Point 232.6±28.7 °C
Exact Mass 210.993927
PSA 88.34000
LogP 1.31
Appearance of Characters white to beige
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.671
Storage condition Store at +4°C
Water Solubility DMSO: >20mg/mL

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 26-36/37/39
RIDADR NONH for all modes of transport
HS Code 2934999090

 Synthetic Route

~85%

Stattic Structure

Stattic

CAS#:19983-44-9

Literature: WO2006/36024 A1, ; Page/Page column 154-155 ;

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Stattic Structure

Stattic

CAS#:19983-44-9

Literature: Journal of the American Chemical Society, , vol. 77, p. 5939,5943

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Stattic Structure

Stattic

CAS#:19983-44-9

Literature: Journal of the American Chemical Society, , vol. 77, p. 5939,5943

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Stattic Structure

Stattic

CAS#:19983-44-9

Literature: Journal of the American Chemical Society, , vol. 77, p. 5939,5943

~%

Stattic Structure

Stattic

CAS#:19983-44-9

Literature: Journal of the American Chemical Society, , vol. 77, p. 5939,5943

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Stattic Structure

Stattic

CAS#:19983-44-9

Literature: Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 963 - 968

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Stattic Structure

Stattic

CAS#:19983-44-9

Literature: Journal of the Chemical Society, , p. 1615,1617

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles20

More Articles
6-Mercaptopurine reduces macrophage activation and gut epithelium proliferation through inhibition of GTPase Rac1.

Inflamm. Bowel Dis. 20(9) , 1487-95, (2014)

Inflammatory bowel disease is characterized by chronic intestinal inflammation. Azathioprine and its metabolite 6-mercaptopurine (6-MP) are effective immunosuppressive drugs that are widely used in pa...

Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway.

Hum. Pathol. 46(2) , 284-94, (2015)

It is hypothesized that cigarette smoke may increase MMP2 and MMP9 secretion through Jak/Stat pathway in the aorta, thereby facilitating abdominal aortic aneurysm (AAA) formation/progression in smoker...

Reduction of RKIP expression promotes nasopharyngeal carcinoma invasion and metastasis by activating Stat3 signaling.

Oncotarget 6 , 16422-36, (2015)

The role and underlying mechanism of Raf kinase inhibitory protein (RKIP) in nasopharyngeal carcinoma (NPC) metastasis remain unclear. Here, we showed that RKIP was downregulated in the NPC with high ...

 Synonyms

6-Nitro-benzo<b>thiophen-1,1-dioxid
6-nitro-benzo[b]thiophene-1,1-dioxide
Benzo[b]thiophene, 6-nitro-, 1,1-dioxide
6-nitro-1H-1λ-benzo[b]thiophene-1,1-dione
6-nitro-1
STAT3 Inhibitor V,Stattic
Benzo[b]thiophene,6-nitro-,1,1-dioxide
6-Nitrobenzo[b]thiophene-1,1-dioxide,Stat three inhibitory compound
6-Nitro-1-benzothiophene 1,1-dioxide
6-nitro-1-benzothiophene-1,1-dioxide
Stattic
Stat three inhibitory compound
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