HTH-01-091
Modify Date: 2024-01-11 18:56:35
HTH-01-091 structure
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Common Name | HTH-01-091 | ||
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| CAS Number | 2000209-42-5 | Molecular Weight | 499.436 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H28Cl2N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HTH-01-091HTH-01-091 is a potent and selective, cell-permeable, ATP-competitive MELK inhibitor with biochemical IC50 of 10.5 nM; displays no significant activity for PIK3CA, mTOR, GSK3A and CDK7 (IC50>600 nM); exhibits substantially improved kinome selectivity in comparison with OTSSP167; induces MELK degradation, but demonstrates poor antiproliferative effects in basal-like breast cancer cell lines. |
| Name | HTH-01-091 |
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| Description | HTH-01-091 is a potent and selective, cell-permeable, ATP-competitive MELK inhibitor with biochemical IC50 of 10.5 nM; displays no significant activity for PIK3CA, mTOR, GSK3A and CDK7 (IC50>600 nM); exhibits substantially improved kinome selectivity in comparison with OTSSP167; induces MELK degradation, but demonstrates poor antiproliferative effects in basal-like breast cancer cell lines. |
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| References | References 1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693. View Related Products by Target MELK |
| Molecular Formula | C26H28Cl2N4O2 |
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| Molecular Weight | 499.436 |