2000209-42-5
2000209-42-5 structure
- Name: HTH-01-091
- Chemical Name: HTH-01-091
- CAS Number: 2000209-42-5
- Molecular Formula: C26H28Cl2N4O2
- Molecular Weight: 499.436
- Catalog: Signaling Pathways Apoptosis RIP kinase
- Create Date: 2020-01-11 20:54:49
- Modify Date: 2024-01-11 18:56:35
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HTH-01-091 is a potent and selective, cell-permeable, ATP-competitive MELK inhibitor with biochemical IC50 of 10.5 nM; displays no significant activity for PIK3CA, mTOR, GSK3A and CDK7 (IC50>600 nM); exhibits substantially improved kinome selectivity in comparison with OTSSP167; induces MELK degradation, but demonstrates poor antiproliferative effects in basal-like breast cancer cell lines.
| Name | HTH-01-091 |
|---|
| Description | HTH-01-091 is a potent and selective, cell-permeable, ATP-competitive MELK inhibitor with biochemical IC50 of 10.5 nM; displays no significant activity for PIK3CA, mTOR, GSK3A and CDK7 (IC50>600 nM); exhibits substantially improved kinome selectivity in comparison with OTSSP167; induces MELK degradation, but demonstrates poor antiproliferative effects in basal-like breast cancer cell lines. |
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| References | References 1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693. View Related Products by Target MELK |
| Molecular Formula | C26H28Cl2N4O2 |
|---|---|
| Molecular Weight | 499.436 |