L-Leucine-13C6

Modify Date: 2024-04-05 18:15:55

L-Leucine-13C6 Structure
L-Leucine-13C6 structure
 Common Name L-Leucine-13C6
CAS Number 201740-84-3 Molecular Weight 137.129
Density 1.0±0.1 g/cm3 Boiling Point N/A
Molecular Formula 13C6H13NO2 Melting Point N/A
MSDS USA Flash Point N/A

 Use of L-Leucine-13C6


L-Leucine-13C6 is the 13C labeled L-Leucine[1]. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[2].

 Names

Name MFCD00144634
Synonym More Synonyms

 L-Leucine-13C6 Biological Activity

Description L-Leucine-13C6 is the 13C labeled L-Leucine[1]. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.  

[3]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 229(1):77.  

[4]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb61(2):409-17.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Molecular Formula 13C6H13NO2
Molecular Weight 137.129
Exact Mass 137.114761
Index of Refraction 1.463

 Synonyms

MFCD00144634
(S)-2-Amino-4-methylpentanoic acid-13C6
13C Labeled L-leucine
L-Leucine-13C6
SILAC Amino Acid
L-(13C6)Leucine
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Chemsrc provides L-Leucine-13C6(CAS#:201740-84-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of L-Leucine-13C6 are included as well.>> amp version: L-Leucine-13C6

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