HBV Capsid inhibitor 3711
Modify Date: 2024-01-07 10:46:46
HBV Capsid inhibitor 3711 structure
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Common Name | HBV Capsid inhibitor 3711 | ||
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| CAS Number | 2041072-40-4 | Molecular Weight | 367.833 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H18ClN3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HBV Capsid inhibitor 3711HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation; decreases extracellular HBV DNA levels and intracellular DNA levels with EC50 of 1.5 and 1.9 uM in a cell model system; shows sensitivity against both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant; decreases levels of HBV DNA contained in both secreted enveloped virion and naked virus particles in supernatant, interferes with capsid formation of the core protein (Cp) assembly domain. |
| Name | HBV Capsid inhibitor 3711 |
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| Description | HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation; decreases extracellular HBV DNA levels and intracellular DNA levels with EC50 of 1.5 and 1.9 uM in a cell model system; shows sensitivity against both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant; decreases levels of HBV DNA contained in both secreted enveloped virion and naked virus particles in supernatant, interferes with capsid formation of the core protein (Cp) assembly domain. |
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| References | References 1. Feng S, et al. ACS Infect Dis. 2018 Mar 9;4(3):257-277. 2. Wang YJ, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):7061-72. View Related Products by Target HBV |
| Molecular Formula | C20H18ClN3O2 |
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| Molecular Weight | 367.833 |