2041072-40-4
2041072-40-4 structure
- Name: HBV Capsid inhibitor 3711
- Chemical Name: HBV Capsid inhibitor 3711
- CAS Number: 2041072-40-4
- Molecular Formula: C20H18ClN3O2
- Molecular Weight: 367.833
- Create Date: 2020-01-11 15:58:50
- Modify Date: 2024-01-07 10:46:46
-
HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation; decreases extracellular HBV DNA levels and intracellular DNA levels with EC50 of 1.5 and 1.9 uM in a cell model system; shows sensitivity against both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant; decreases levels of HBV DNA contained in both secreted enveloped virion and naked virus particles in supernatant, interferes with capsid formation of the core protein (Cp) assembly domain.
| Name | HBV Capsid inhibitor 3711 |
|---|
| Description | HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation; decreases extracellular HBV DNA levels and intracellular DNA levels with EC50 of 1.5 and 1.9 uM in a cell model system; shows sensitivity against both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant; decreases levels of HBV DNA contained in both secreted enveloped virion and naked virus particles in supernatant, interferes with capsid formation of the core protein (Cp) assembly domain. |
|---|---|
| References | References 1. Feng S, et al. ACS Infect Dis. 2018 Mar 9;4(3):257-277. 2. Wang YJ, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):7061-72. View Related Products by Target HBV |
| Molecular Formula | C20H18ClN3O2 |
|---|---|
| Molecular Weight | 367.833 |