BU 224 hydrochloride
Modify Date: 2024-04-06 08:24:21
BU 224 hydrochloride structure
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Common Name | BU 224 hydrochloride | ||
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| CAS Number | 205437-64-5 | Molecular Weight | 233.69700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H12ClN3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BU 224 hydrochlorideBU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research[1][2][3]. |
| Name | 2-(4,5-Dihydro-1H-imidazol-2-yl)quinoline hydrochloride (1:1) |
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| Description | BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research[1][2][3]. |
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| Related Catalog | |
| Target |
TNF-α |
| In Vivo | BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) improves behavioural performance and memory function in 5XFAD mice[1]. BU224 hydrochloride (5 mg/kg, IP, twice a day for 10 days) reduces levels of the microglial marker Iba1 and pro-inflammatory cytokines IL-1β and TNF-α and increased the expression of astrocytic marker GFAP in 5XFAD mice[1]. BU224 hydrochloride (10 mg/kg, IP, once) reduces immobility of rats in the FST (forced swim test), indicative of antidepressant-like activity[2]. Animal Model: 5XFAD mice and and WT littermates (6-month-old)[1] Dosage: 0 mg/kg, 5 mg/kg Administration: IP, twice a day for 10 days Result: Significantly increased immobility (54% increased freezing), and reversed memory deficits secondary to the deposition of Aβ in the brain. |
| References |
| Molecular Formula | C12H12ClN3 |
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| Molecular Weight | 233.69700 |
| Exact Mass | 233.07200 |
| PSA | 37.28000 |
| LogP | 2.15100 |