4-Amino-5-bromo-2-chloropyrimidine

Modify Date: 2024-01-02 16:23:10

4-Amino-5-bromo-2-chloropyrimidine structure	Common Name	4-Amino-5-bromo-2-chloropyrimidine
	CAS Number	205672-25-9	Molecular Weight	208.444
	Density	2.0±0.1 g/cm3	Boiling Point	369.8±22.0 °C at 760 mmHg
	Molecular Formula	C₄H₃BrClN₃	Melting Point	N/A
	MSDS	USA	Flash Point	177.5±22.3 °C

Name	5-bromo-2-chloropyrimidin-4-amine
Synonym	More Synonyms

Density	2.0±0.1 g/cm3
Boiling Point	369.8±22.0 °C at 760 mmHg
Molecular Formula	C₄H₃BrClN₃
Molecular Weight	208.444
Flash Point	177.5±22.3 °C
Exact Mass	206.919876
PSA	51.80000
LogP	1.93
Appearance of Characters	Liquid \| Clear brown to purple
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.660
Water Solubility	Slightly soluble in water.

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
5-Bromo-2-chloropyrimidin-4-amine
Product Name:
Synonyms:

Section2. Hazards identiﬁcation

Harmful by inhalation, in contact with skin, and if swallowed.
H301:Toxic if swallowed
H315:Causes skin irritation
H318:Causes serious eye damage
H335:May cause respiratory irritation
Avoid breathing dust/fume/gas/mist/vapours/spray
P261:
P280:Wear protective gloves/protective clothing/eye protection/face protection
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

Section3. Composition/information on ingredients.
5-Bromo-2-chloropyrimidin-4-amine
Ingredient name:
CAS number:205672-25-9

Section4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Not speciﬁed
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C4H3BrClN3
Molecular weight:208.4

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen bromide.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
UN Number:UN2811 Class: 6.1 Packing group: III
Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. (5-Bromo-2-chloropyrimidin-4-amine)

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

Hazard Codes	Xi
Risk Phrases	22-37/38-41-36/37/38
Safety Phrases	26-39-36/37/39
HS Code	2933599090

5-Bromo-2,4-dic...

CAS#:36082-50-5

~99%

4-Amino-5-bromo...

CAS#:205672-25-9

Literature: KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; NOBLE, Stewart, A. Patent: WO2011/112766 A2, 2011 ; Location in patent: Page/Page column 125; 126 ;

Precursor 1
CAS#:36082-50-5 5-Bromo-2,4-dic...
DownStream 2
CAS#:1059174-68-3 4-Amino-5-bromo... CAS#:335654-05-2 2-chloro-5-(2-e...

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%