Tetrahydromagnolol

Modify Date: 2024-01-07 09:21:37

Tetrahydromagnolol Structure
Tetrahydromagnolol structure
Common Name Tetrahydromagnolol
CAS Number 20601-85-8 Molecular Weight 270.366
Density 1.1±0.1 g/cm3 Boiling Point 400.5±40.0 °C at 760 mmHg
Molecular Formula C18H22O2 Melting Point N/A
MSDS N/A Flash Point 182.2±21.9 °C

 Use of Tetrahydromagnolol


Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1].

 Names

Name 2-(2-hydroxy-5-propylphenyl)-4-propylphenol
Synonym More Synonyms

 Tetrahydromagnolol Biological Activity

Description Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1].
Related Catalog
Target

CB2:170 nM (EC50)

CB2:416 nM (Ki)

CB1:9010 nM (EC50)

CB1:2260 nM (Ki)

GPR55 receptor

References

[1]. Alexander Fuchs, et al. The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists. PLoS One. 2013 Oct 30;8(10):e77739.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 400.5±40.0 °C at 760 mmHg
Molecular Formula C18H22O2
Molecular Weight 270.366
Flash Point 182.2±21.9 °C
Exact Mass 270.161987
PSA 40.46000
LogP 4.95
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.577

 Safety Information

HS Code 2907299090

 Synthetic Route

 Customs

HS Code 2907299090
Summary 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

 Synonyms

MLO
[1,1'-Biphenyl]-2,2'-diol, 5,5'-dipropyl-
2,2'-dihydroxy-5,5'-dipropylbiphenyl
5,5'-propyl-2,2'-dihydroxy-1,1'-biphenyl
5,5'-Dipropyl-2,2'-biphenyldiol
5.5'-Dipropyl-biphenyl-2.2'-diol
5,5'-dipropylbiphenyl-2,2'-diol
tetrahydro-magnolol
6,6'-Dihydroxy-3,3'-dipropyl-biphenyl
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