BD1063 (dhydrochloride)

Modify Date: 2024-01-09 04:25:31

BD1063 (dhydrochloride) structure	Common Name	BD1063 (dhydrochloride)
	CAS Number	206996-13-6	Molecular Weight	346.12300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₂₀Cl₄N₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of BD1063 (dhydrochloride)

BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.

Name	1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine
Synonym	More Synonyms

Description	BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Research Areas >> Metabolic Disease
In Vivo	BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls. BD1063 also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule[1]. BD1063 dose-dependently reduces binge-like eating and the regularity of food responding, and blocks the increased eating rate in Palatable rats. In the light/dark conflict test, BD1063 antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity[2]. The administration of BD1063 30 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice. Moreover, the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia[3].
Animal Admin	Rats: BD1063 is solubilized in isotonic saline and injected subcutaneously (s.c. 1 ml/kg), 15 min before testing. Rats are pretreated with BD1063 (0, 4.4, 7 and 11 mg/kg of body weight, free base weights, s.c.) using a within-subject Latin square design. sP rats: Rats are pretreated with BD1063 (0, 3, 4.4, 7 and 11 mg/kg of body weight, free base basis, s.c.) using a within-subject Latin square design[1].
References	[1]. Sabino V, et al. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology. 2009 May;34(6):1482-93. [2]. Cottone P, et al. Antagonism of sigma-1 receptors blocks compulsive-like eating. Neuropsychopharmacology. 2012 Nov;37(12):2593-604. [3]. Nieto FR, et al. Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice. J Pain. 2012 Nov;13(11):1107-21.

Molecular Formula	C₁₃H₂₀Cl₄N₂
Molecular Weight	346.12300
Exact Mass	344.03800
PSA	6.48000
LogP	4.26310
Storage condition	-20℃

BD1063 (dhydrochloride) MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport

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BD 1063 dihydrochloride

BD 1063 Dihydrochloride

1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride BD1063 dihydrochloride

Tocris-0883

BD1063 (dhydrochloride)