L-threo-PPMP

Modify Date: 2024-01-10 17:21:51

L-threo-PPMP Structure
L-threo-PPMP structure
Common Name L-threo-PPMP
CAS Number 207278-87-3 Molecular Weight 474.72
Density N/A Boiling Point N/A
Molecular Formula C29H50N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of L-threo-PPMP


L-threo-PPMP is a GlcT (UDP-Glc: Ceramide β1,1glucosyltransferase) inhibitor. L-threo-PPMP inhibits glycosphingolipid biosynthesis and induces apoptosis. L-threo-PPMP has anti-cancer activity[1].

 Names

Name L-THREO-1-PHENYL-2-HEXADECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
Synonym More Synonyms

 L-threo-PPMP Biological Activity

Description L-threo-PPMP is a GlcT (UDP-Glc: Ceramide β1,1glucosyltransferase) inhibitor. L-threo-PPMP inhibits glycosphingolipid biosynthesis and induces apoptosis. L-threo-PPMP has anti-cancer activity[1].
Related Catalog
In Vitro L-threo-PPMP (0.5-20 μM) induces apoptosis in carcinoma (Colo-205; SKBR3) cells after 6 h and damaging DNA between 24 and 48 h after treatment[1]. L-threo-PPMP (1-16 μM; 48 hours) includes Caspase-3 activation in breast cancer SKBR3 cells[1].
References

[1]. Subhash Basu, et al. Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP. Glycoconj J. 2004;20(3):157-68.

 Chemical & Physical Properties

Molecular Formula C29H50N2O3
Molecular Weight 474.72

 Safety Information

Hazard Codes Xi

 Synonyms

L-threo-PPMP